Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50021123
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human recombinant VEGFR2 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
KU Leuven

Curated by ChEMBL
LigandPNGBDBM50311470(CHEMBL1079742 | Erlotinib | CP-358774-01 | OSI-774...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human EGFR L858R mutant by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant RAF-1 (305 to 648 residues) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of mouse recombinant VEGFR2 (785 to 1367 residues) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
KU Leuven

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant KIT (544 to 976 residues) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant PDGFRbeta (561 to 1106) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant VEGFR1 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant VEGFR3 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 46nMAssay Description:Inhibition of mouse recombinant VEGFR3 (818 to 1363 residues) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed