Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50021630
LigandPNGBDBM283307(US10023543, Example 85 | 4-[2-(4-amino-piperidin-1...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence b...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50153586(CHEMBL3775474 | US10053456, 120 | US9718814, 71 | ...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590442(CHEMBL5029010)
Affinity DataIC50: 4nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 5nMAssay Description:Inhibition of 20s constitutive proteasome beta-5c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDCN1-like protein 1(Human)TBA
LigandPNGBDBM50621125(CHEMBL5315233)
Affinity DataIC50: 11nMAssay Description:Inhibition of DCN1 (unknown origin) by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50642829(CHEMBL5583825)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Baculovirus infected Sf9 cells using AMC-K(Ac)GL as substrate incubated for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590443(Seclidemstat | Sp-2577 | SP-2577 | SP2577 | SECLID...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590443(Seclidemstat | Sp-2577 | SP-2577 | SP2577 | SECLID...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50: 13nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His-tagged human recombinant BRD2 BD2 expressed in Escherichia coli BL21 (DE3) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His-tagged human LSD1 expressed as Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 45 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDCN1-like protein 1(Human)TBA
LigandPNGBDBM50642832(CHEMBL5591297)
Affinity DataIC50: 15nMAssay Description:Inhibition of DCN1 (unknown origin) by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 16nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 18nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50618605(Incb 59872 | Incb-059872 | INCB059872 | INCB-05987...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50618605(Incb 59872 | Incb-059872 | INCB059872 | INCB-05987...)
Affinity DataIC50: 18nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 18nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant LSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 24nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human BRD4 BD2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50: 33nMAssay Description:Inhibition of human BRD4 BD2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 33nMAssay Description:Inhibition of VEGFR2 (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642834(CHEMBL5591988)
Affinity DataIC50: 42nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  43nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50642829(CHEMBL5583825)
Affinity DataIC50: 50nMAssay Description:Inhibition of human LSD1 by luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM195611(GSKJ1)
Affinity DataIC50: 60nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50594960(CHEMBL5182796)
Affinity DataIC50: 63nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50594947(VAFIDEMSTAT | Vafidemstat | ORY-2001)
Affinity DataIC50: 73nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human BRD4 BD1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50: 77nMAssay Description:Inhibition of human BRD4 BD1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant BRD4 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of N-terminal His-tagged human recombinant BRD2 BD2 expressed in Escherichia coli BL21 (DE3) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM50642829(CHEMBL5583825)
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant HDAC8More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 101nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using fluorogenic ADHP as substrate preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642831(CHEMBL5418631)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642833(CHEMBL5575816)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50621125(CHEMBL5315233)
Affinity DataIC50: 288nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642830(CHEMBL5565803)
Affinity DataIC50: 300nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 300nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 300nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642832(CHEMBL5591297)
Affinity DataIC50: 339nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50606480(CHEMBL5219231)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant LSD1 using fluorogenic ADHP as substrate preincubated for 30 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of human LSD1 by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant HDAC3 expressed in baculovirus infected insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50621638(CHEMBL4440976)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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