Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50022700
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598859BDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50555101BDBM50555101(CHEMBL4778517)
Affinity DataKd:  170nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239291BDBM50239291(CHEMBL4091463)
Affinity DataIC50: 300nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653202BDBM50653202(CHEMBL2028187)
Affinity DataIC50: 340nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3B(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075103BDBM50075103(CHEBI:48202 | Nanafrocin)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 83922BDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653207BDBM50653207(CHEMBL6102079)
Affinity DataIC50: 1.60E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 71542BDBM71542(Primaquine bisphosphate | N4-(6-methoxy-8-quinolin...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 24776BDBM24776(1,4-dihydronaphthalene-1,4-dione | 1,4-Naphthoquin...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 51317BDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653209BDBM50653209(CHEMBL6102871)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at human oxytocin receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653204BDBM50653204(CHEMBL6102797)
Affinity DataIC50: 3.30E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 57938BDBM57938(cid_160254 | MLS001049002 | (1R)-1,6,6-trimethyl-2...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075193BDBM50075193(CHEMBL3414630)
Affinity DataIC50: 4.90E+3nMAssay Description:Antagonist activity at human oxytocin receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50855BDBM50855(ALPHA-ERGOCRYPTINE | MLS000069839 | SMR000058703 |...)
Affinity DataIC50: 4.90E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012070BDBM50012070(CHEMBL295316 | plumbagin | 5-hydroxy-2-methylnapht...)
Affinity DataIC50: 5.70E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653203BDBM50653203(CHEMBL6149804)
Affinity DataIC50: 5.90E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315537BDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 6.00E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3B(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430056BDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50: 7.50E+3nMAssay Description:Antagonist activity at human oxytocin receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430056BDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50: 8.00E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075193BDBM50075193(CHEMBL3414630)
Affinity DataIC50: 8.20E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315537BDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 1.10E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336799BDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataIC50: 1.20E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430056BDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50: 1.25E+4nMAssay Description:Antagonist activity at human vasopressin V2 receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336799BDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315537BDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653209BDBM50653209(CHEMBL6102871)
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at human vasopressin V2 receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239291BDBM50239291(CHEMBL4091463)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336799BDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataIC50: 2.10E+4nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653208BDBM50653208(CHEMBL6144044)
Affinity DataIC50: 2.80E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653206BDBM50653206(CHEMBL167773)
Affinity DataIC50: 3.60E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 4.10E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378739BDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378739BDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 6.10E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50608076BDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+4nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378739BDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 7.90E+4nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300028BDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.12E+5nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572787BDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50608082BDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50555100BDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.00E+5nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50608081BDBM50608081(CHEMBL5270364)
Affinity DataKd:  7.31E+5nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
Central China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653205BDBM50653205(CHEMBL6133519)
Affinity DataIC50: 8.90E+5nMAssay Description:Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed