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Target
Beta-2 adrenergic receptor
Ligand
BDBM50108088
Substrate
n/a
Meas. Tech.
ChEMBL_1700068 (CHEMBL4051050)
EC50
>10000±n/a nM
Citation
 Wada, Y; Nakano, S; Morimoto, A; Kasahara, KI; Hayashi, T; Takada, Y; Suzuki, H; Niwa-Sakai, M; Ohashi, S; Mori, M; Hirokawa, T; Shuto, S Discovery of Novel Indazole Derivatives as Orally Available? J Med Chem 60:3252-3265 (2017) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50108088
Synonyms:
CHEMBL3601305
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4S
Mol. Mass.:
432.536
SMILES:
CC(C)c1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 |r|
Structure:
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