Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM50096700
Substrate
n/a
Meas. Tech.
ChEMBL_214527 (CHEMBL819519)
IC50
31000±n/a nM
Citation
 Wipf, P; Aslan, DC; Southwick, EC; Lazo, JS Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. Bioorg Med Chem Lett 11:313-7 (2001) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50096700
Synonyms:
(E)-2-p-Tolyl-ethenesulfonic acid [5-propyl-4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-amide | CHEMBL110922
Type:
Small organic molecule
Emp. Form.:
C22H21F3N2O2S2
Mol. Mass.:
466.54
SMILES:
CCCc1sc(NS(=O)(=O)\C=C\c2ccc(C)cc2)nc1-c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: