Reaction Details
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Ceramide glucosyltransferase
Ligand
BDBM50585887
Substrate
n/a
Meas. Tech.
ChEMBL_2164214 (CHEMBL5049075)
IC50
1000±n/a nM
Citation
Tanaka, Y; Seto, M; Kakegawa, K; Takami, K; Kikuchi, F; Yamamoto, T; Nakamura, M; Daini, M; Murakami, M; Ohashi, T; Kasahara, T; Wang, J; Ikeda, Z; Wada, Y; Puenner, F; Fujii, T; Inazuka, M; Sato, S; Suzaki, T; Oak, JH; Takai, Y; Kohara, H; Kimoto, K; Oki, H; Mikami, S; Sasaki, M; Tanaka, Y Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem 65:4270-4290 (2022) [PubMed] Article More Info.:
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
Inhibitor
Name:
BDBM50585887
Synonyms:
CHEMBL5088946
Type:
Small organic molecule
Emp. Form.:
C20H15FN2O2
Mol. Mass.:
334.3437
SMILES:
COc1ccccc1-c1nccc2C(=O)N(Cc12)c1ccc(F)cc1
Structure:
