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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM13923
Substrate
n/a
Meas. Tech.
ChEMBL_321443 (CHEMBL880251)
IC50
>25000±n/a nM
Citation
 Fink, BE; Vite, GD; Mastalerz, H; Kadow, JF; Kim, SH; Leavitt, KJ; Du, K; Crews, D; Mitt, T; Wong, TW; Hunt, JT; Vyas, DM; Tokarski, JS New dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorg Med Chem Lett 15:4774-9 (2005) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM13923
Synonyms:
2-(1H-imidazol-1-yl)ethyl N-{4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethylpyrrolo[1,2-a][1,2,4]triazin-6-yl}carbamate | CHEMBL412367 | pyrrolo[2,1-f][1,2,4]triazine analog 9b
Type:
Small organic molecule
Emp. Form.:
C28H27N9O2
Mol. Mass.:
521.5731
SMILES:
CCc1c(NC(=O)OCCn2ccnc2)cn2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12
Structure:
Search PDB for entries with ligand similarity: