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Target
Stimulator of interferon genes protein
Ligand
BDBM50506263
Substrate
n/a
Meas. Tech.
ChEMBL_2248230 (CHEMBL5162440)
Kd
<0.010000±n/a nM
Citation
 Chang, W; Altman, MD; Lesburg, CA; Perera, SA; Piesvaux, JA; Schroeder, GK; Wyss, DF; Cemerski, S; Chen, Y; DiNunzio, E; Haidle, AM; Ho, T; Kariv, I; Knemeyer, I; Kopinja, JE; Lacey, BM; Laskey, J; Lim, J; Long, BJ; Ma, Y; Maddess, ML; Pan, BS; Presland, JP; Spooner, E; Steinhuebel, D; Truong, Q; Zhang, Z; Fu, J; Addona, GH; Northrup, AB; Parmee, E; Tata, JR; Bennett, DJ; Cumming, JN; Siu, T; Trotter, BW Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer. J Med Chem 65:5675-5689 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Endoplasmic reticulum interferon stimulator | Eris | MMITA | Mediator of IRF3 activation | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein | Sting | Sting1 | Synonyms=Eris | Tmem173 | Transmembrane protein 173 | mSTING
Type:
PROTEIN
Mol. Mass.:
42834.49
Organism:
Mus musculus
Description:
ChEMBL_119061
Residue:
378
Sequence:
MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLLKNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMFGLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI
  
Inhibitor
Name:
BDBM50506263
Synonyms:
CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP
Type:
Small organic molecule
Emp. Form.:
C20H24N10O13P2
Mol. Mass.:
674.4113
SMILES:
[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12 |r|
Structure:
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