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Found 174 with Last Name = 'wyss' and Initial = 'df'
TargetCathepsin D(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)...)
Affinity DataKi:  740nMAssay Description:Inhibition of human cathepsin D preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145828(2-(4-{3-[(S)-1-Carboxy-2-(4-hydroxy-3,5-diiodo-phe...)
Affinity DataKi:  800nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145844(2-(4-{3-[(S)-1-tert-Butoxycarbonyl-2-(4-hydroxy-3,...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145820(3-(4-Hydroxy-3,5-diiodo-phenyl)-propionic acid | C...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145823(3-(4-Hydroxy-3,5-diiodo-phenyl)-3-phenyl-propionic...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145804(3-(4-Hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145815(4-(4-Hydroxy-3,5-diiodo-phenyl)-butyric acid | CHE...)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145808((R)-2-Acetylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145825((R)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145833((S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  3.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145835(4-Hydroxy-3,5-diiodo-benzoic acid | CHEMBL83650)
Affinity DataKi:  6.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145827(CHEMBL311209 | N-[(4-methylbenzene)sulfonamido]ben...)
Affinity DataKi:  6.50E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604556(CHEMBL5175703)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509399(CHEMBL4468010)
Affinity DataIC50:  0.300nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataIC50:  0.700nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM573971(US11453697, Example 247)
Affinity DataIC50:  1.10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509408(CHEMBL4459563)
Affinity DataIC50:  1.30nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509422(CHEMBL4476079)
Affinity DataIC50:  1.40nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM573856(US11453697, Example 20)
Affinity DataIC50:  1.40nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509431(CHEMBL4589856)
Affinity DataIC50:  1.5nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604561(CHEMBL5197904)
Affinity DataIC50:  1.70nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50:  1.80nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50604563(CHEMBL5201164)
Affinity DataIC50:  1.90nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604560(CHEMBL5180005)
Affinity DataIC50:  2nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604555(CHEMBL5181746)
Affinity DataIC50:  2.90nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604562(CHEMBL5185127)
Affinity DataIC50:  3.10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509412(CHEMBL4474321 | US11453697, Example 1)
Affinity DataIC50:  3.5nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604559(CHEMBL5174023)
Affinity DataIC50:  3.70nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604557(CHEMBL5191008)
Affinity DataIC50:  4.20nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509430(CHEMBL4570468)
Affinity DataIC50:  8.30nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50509425(CHEMBL4566174 | US11453697, Example 27)
Affinity DataIC50:  10nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604558(CHEMBL5205731)
Affinity DataIC50:  16nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300237((R)-5-(2-Cyclohexylethyl)-5-(cyclohexylmethyl)-3-[...)
Affinity DataIC50:  27nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50582513(CHEMBL5093161)
Affinity DataIC50:  45nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380310(CHEMBL2017619)
Affinity DataIC50:  90nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380309(CHEMBL2017463)
Affinity DataIC50:  100nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50:  110nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380305(CHEMBL2017459)
Affinity DataIC50:  130nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300236(CHEMBL568942 | rac-3-[(3-Butylureido)methyl]benzyl...)
Affinity DataIC50:  350nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380308(CHEMBL2017462)
Affinity DataIC50:  440nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380304(CHEMBL2017458)
Affinity DataIC50:  600nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)...)
Affinity DataIC50:  605nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380306(CHEMBL2017460)
Affinity DataIC50:  650nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380307(CHEMBL2017461)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300233(CHEMBL571249 | rac-3-[(3-Butylureido)methyl]benzyl...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380298(CHEMBL2017452)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300235(CHEMBL571728 | rac-3-[(3-Butyl-ureidomethyl)benzyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300232(CHEMBL568968 | rac-3-[(3-Butylureidomethyl)benzyl]...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362169(CHEMBL1938680)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 2 uM ATP by DELFIA a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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