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Target
Collagenase 3
Ligand
BDBM50224854
Substrate
n/a
Meas. Tech.
ChEMBL_458357 (CHEMBL941691)
IC50
0.6±n/a nM
Citation
Freeman-Cook, KD; Reiter, LA; Noe, MC; Antipas, AS; Danley, DE; Datta, K; Downs, JT; Eisenbeis, S; Eskra, JD; Garmene, DJ; Greer, EM; Griffiths, RJ; Guzman, R; Hardink, JR; Janat, F; Jones, CS; Martinelli, GJ; Mitchell, PG; Laird, ER; Liras, JL; Lopresti-Morrow, LL; Pandit, J; Reilly, UD; Robertson, D; Vaughn-Bowser, ML; Wolf-Gouviea, LA; Yocum, SA Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett 17:6529-34 (2007) [PubMed] Article
More Info.:
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Human
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC