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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50352720
Substrate
n/a
Meas. Tech.
ChEMBL_766795 (CHEMBL1827735)
IC50
10.3±n/a nM
Citation
 Seo, HJ; Park, EJ; Kim, MJ; Kang, SY; Lee, SH; Kim, HJ; Lee, KN; Jung, ME; Lee, M; Kim, MS; Son, EJ; Park, WK; Kim, J; Lee, J Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. J Med Chem 54:6305-18 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50352720
Synonyms:
CHEMBL1823216 | US8835436, Example 140
Type:
Small organic molecule
Emp. Form.:
C27H34FN5O2
Mol. Mass.:
479.5896
SMILES:
Cc1nc(C(=O)NC[C@H](O)CN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1F |r,wU:8.8,(-5.84,-16.71,;-5.06,-15.38,;-3.52,-15.38,;-3.04,-13.92,;-1.71,-13.15,;-1.71,-11.61,;-.38,-13.92,;.96,-13.15,;2.29,-13.92,;2.29,-15.46,;3.62,-13.15,;4.95,-13.92,;6.28,-13.14,;7.61,-13.9,;7.62,-15.44,;6.28,-16.22,;4.94,-15.45,;8.95,-16.21,;10.28,-15.43,;11.62,-16.19,;11.62,-17.73,;10.28,-18.51,;10.28,-20.05,;8.95,-17.74,;7.62,-18.51,;-4.29,-13.01,;-4.3,-11.47,;-5.54,-13.92,;-6.87,-13.15,;-6.86,-11.61,;-8.2,-10.84,;-9.54,-11.6,;-9.53,-13.16,;-8.2,-13.92,;-8.19,-15.46,)|
Structure:
Search PDB for entries with ligand similarity: