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Found 1299 with Last Name = 'son' and Initial = 'ej'
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203205((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to 5-HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313283(1-{2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity to 5-HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313283(1-{2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.810nMAssay Description:Inhibition of 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244564(4-(naphthalen-2-ylsulfonyl)-3-phenyl-N-((R)-6-(pip...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244566((2R,3S)-2,3-dihydroxy-4-(naphthalen-2-ylsulfonyl)-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313283(1-{2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313283(1-{2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244617((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50069447(1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-e...)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to 5-HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244472((S)-3-methoxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244439((2R,3S)-4-(2,3-dichlorophenylsulfonyl)-2,3-dihydro...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244437((2R,3S)-4-(4-tert-butylphenylsulfonyl)-2,3-dihydro...)
Affinity DataKi:  15.8nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244438((2R,3S)-4-(3,4-dichlorophenylsulfonyl)-2,3-dihydro...)
Affinity DataKi:  16.9nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244470((S)-2-hydroxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  19.1nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313284((S)-2-((7-fluoro-2,3-dihydro-1H-inden-4-yloxy)meth...)
Affinity DataKi:  21nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313284((S)-2-((7-fluoro-2,3-dihydro-1H-inden-4-yloxy)meth...)
Affinity DataKi:  21nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244471((R)-2-hydroxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  23.5nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244435((S)-3-hydroxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  41.4nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114942(2-(3,5-Bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluo...)
Affinity DataKi:  43nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244568((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Affinity DataKi:  43.8nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244618((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Affinity DataKi:  48.4nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244619((2R,3S)-4-(3-chlorophenylsulfonyl)-2,3-dihydroxy-N...)
Affinity DataKi:  54.4nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244434((R)-4-(naphthalen-2-ylsulfonyl)-N-(6-(piperidin-1-...)
Affinity DataKi:  59.9nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM82022(2-(Phenylamino)ado (CV-1808) | 2-[6-Amino-2-(3-cyc...)
Affinity DataKi:  76nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313284((S)-2-((7-fluoro-2,3-dihydro-1H-inden-4-yloxy)meth...)
Affinity DataKi:  86nMAssay Description:Inhibition of 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313284((S)-2-((7-fluoro-2,3-dihydro-1H-inden-4-yloxy)meth...)
Affinity DataKi:  86nMAssay Description:Binding affinity to 5-HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  98nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244436((R)-3-hydroxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180545(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-(2-methyl-...)
Affinity DataKi:  100nMAssay Description:Displacement of [35S]labelled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244620((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Affinity DataKi:  138nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM14487((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataKi:  150nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244565((R)-2-methoxy-4-(naphthalen-2-ylsulfonyl)-N-((R)-6...)
Affinity DataKi:  169nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114962(CHEMBL3085130 | N-[4-(4-Benzyl-4-hydroxy-piperidin...)
Affinity DataKi:  260nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50069447(1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-e...)
Affinity DataKi:  290nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM14487((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataKi:  290nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance as...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180546(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenyl-8-a...)
Affinity DataKi:  300nMAssay Description:Displacement of [35S]labelled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179771(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataKi:  327nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179768(3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-[4-(...)
Affinity DataKi:  364nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  395nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114954(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxo-1-o...)
Affinity DataKi:  400nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114955(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-methyl-...)
Affinity DataKi:  460nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114959(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxo-2-o...)
Affinity DataKi:  490nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50244567((2R,3S)-2,3-dihydroxy-4-(phenylsulfonyl)-N-((R)-6-...)
Affinity DataKi:  565nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114963(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataKi:  710nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114960(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxa-8-a...)
Affinity DataKi:  730nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179773(2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataKi:  787nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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