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Target
TGF-beta receptor type-1
Ligand
BDBM50365531
Substrate
n/a
Meas. Tech.
ChEMBL_808015 (CHEMBL1961074)
IC50
760±n/a nM
Citation
 Amada, H; Sekiguchi, Y; Ono, N; Matsunaga, Y; Koami, T; Asanuma, H; Shiozawa, F; Endo, M; Ikeda, A; Aoki, M; Fujimoto, N; Wada, R; Sato, M Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-ß type I receptor kinase. Bioorg Med Chem Lett 22:2024-9 (2012) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50365531
Synonyms:
CHEMBL1957650
Type:
Small organic molecule
Emp. Form.:
C22H18N4O3S
Mol. Mass.:
418.468
SMILES:
CCc1csc(n1)-c1[nH]c(nc1-c1ccc2OCOc2c1)-c1ccc(cc1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: