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Found 281 with Last Name = 'shiozawa' and Initial = 'f'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305129(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305140(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305119(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305131(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305139(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305117(7-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305142(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305138(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305121(7-(2-(dimethylamino)ethoxy)-2-(4-(phenylamino)phen...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305125(2-(4-(3-(2,6-dichlorophenyl)ureido)phenyl)-7-(2-(d...)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305141(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305135(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305122(2-(4-(2,6-dichlorobenzylamino)phenyl)-7-(2-(dimeth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305118(7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305143(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305130(6-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305132(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305134(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305123(CHEMBL595625 | benzyl 4-(3-carbamoyl-7-(2-(dimethy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305124(7-(2-(dimethylamino)ethoxy)-2-(4-(3-phenylureido)p...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305128(7-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305145(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305136(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305120(2-(4-aminophenyl)-7-(2-(dimethylamino)ethoxy)-9,10...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305127(6-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305144(2-(4-phenoxyphenyl)-7-(pyridin-2-ylmethoxy)-9,10-d...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365553(CHEMBL1957675)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human recombinant GST-fused ALK5 using TMB substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305137(2-(4-phenoxyphenyl)-6-(pyridin-3-ylmethoxy)-9,10-d...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305116(2-(4-phenoxyphenyl)-7-(pyridin-4-ylmethoxy)-9,10-d...)
Affinity DataIC50:  10nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503838(CHEMBL4450704)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242568(US9422240, 1-378)
Affinity DataIC50:  14nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242567(US9422240, 1-377)
Affinity DataIC50:  15nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242554(US9422240, 1-296)
Affinity DataIC50:  15nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503834(CHEMBL4591009)
Affinity DataIC50:  17nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503827(CHEMBL4439652)
Affinity DataIC50:  17nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503822(CHEMBL4460788)
Affinity DataIC50:  19nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242526(US9422240, 1-4)
Affinity DataIC50:  19nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242563(US9422240, 1-366)
Affinity DataIC50:  19nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503841(CHEMBL4554040)
Affinity DataIC50:  20nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242577(US9422240, 1-443)
Affinity DataIC50:  21nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503835(CHEMBL4524341)
Affinity DataIC50:  21nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 30 mins in presence of [14C]-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242566(US9422240, 1-376)
Affinity DataIC50:  22nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503838(CHEMBL4450704)
Affinity DataIC50:  22nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 30 mins in presence of [14C]-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50503822(CHEMBL4460788)
Affinity DataIC50:  23nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 30 mins in presence of [14C]-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM242542(US9422240, 1-265 | US9422240, 1-355)
Affinity DataIC50:  24nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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