Reaction Details Report a problem with these data
Target
Leucine--tRNA ligase, cytoplasmic
Ligand
BDBM50370987
Substrate
n/a
Meas. Tech.
ChEMBL_437219 (CHEMBL906617)
IC50
2100±n/a nM
Citation
Rock, FL; Mao, W; Yaremchuk, A; Tukalo, M; Crépin, T; Zhou, H; Zhang, YK; Hernandez, V; Akama, T; Baker, SJ; Plattner, JJ; Shapiro, L; Martinis, SA; Benkovic, SJ; Cusack, S; Alley, MR An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316:1759-1761 (2007) [PubMed] Article
More Info.:
Target
Name:
Leucine--tRNA ligase, cytoplasmic
Synonyms:
CDC60 | LeuRS | Leucine--tRNA ligase, cytoplasmic | Leucyl-tRNA synthetase | Leucyl-tRNA synthetase, cytoplasmic | SYLC_YEAST
Type:
PROTEIN
Mol. Mass.:
124127.98
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_437218
Residue:
1090
Sequence:
MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEIGPLGISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQSQCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPGNPGVVFQNI