Reaction Details Report a problem with these data
Target
DNA gyrase subunit B
Ligand
BDBM50010371
Substrate
n/a
Meas. Tech.
ChEMBL_1353018 (CHEMBL3270626)
IC50
4.0±n/a nM
Citation
Ahuja, V; Basavarajappa, H; P, SH; Boriack-Sjodin, PA; McKinney, D; Ganguly, S; Kranthi, U; Gaonkar, S; Jena, Lk; Ghorpade, SR; Ghosh, A; Barde, S; Kale, MG; Koushik, K; Kumar, CN; Manjunatha, MR; Ogg, D; Panduga, V; Ramya, VK; Reddy, J; Kumar, KN; Giridhar, J; Rudrapatna, S; Sharma, S; Tucker, JA; Vachaspati, P; Waterson, D; de Sousa, SM Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B. Cell Chem Biol 56:8834-48 (2013) [PubMed] Article
More Info.:
Target
Name:
DNA gyrase subunit B
Synonyms:
GYRB_MYCSM | gyrB
Type:
PROTEIN
Mol. Mass.:
74505.25
Organism:
Mycobacterium smegmatis
Description:
ChEMBL_107961
Residue:
675
Sequence:
MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEATGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKKINVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARRSFITRNAKDVRFLDV