Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50422435
Substrate
n/a
Meas. Tech.
ChEMBL_162009 (CHEMBL764180)
Ki
0.104000±n/a nM
Citation
 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. J Med Chem 46:155-60 (2002) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50422435
Synonyms:
CHEMBL2311112
Type:
Small organic molecule
Emp. Form.:
C10H13N5O4
Mol. Mass.:
267.2413
SMILES:
OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1[nH]nc2c1nc[nH]c2=O
Structure:
Search PDB for entries with ligand similarity: