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Target
Dihydrofolate reductase
Ligand
BDBM50608615
Substrate
n/a
Meas. Tech.
ChEMBL_2274304
Ki
35860±n/a nM
Citation
 He, J; Qiao, W; An, Q; Yang, T; Luo, Y Dihydrofolate reductase inhibitors for use as antimicrobial agents. Eur J Med Chem 195:0 (2020) [PubMed] 
Target
Name:
Dihydrofolate reductase
Synonyms:
Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA
Type:
Enzyme
Mol. Mass.:
17991.61
Organism:
Escherichia coli
Description:
E. coli DHFR was expressed in BL21, and purified to homogeneity.
Residue:
159
Sequence:
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
  
Inhibitor
Name:
BDBM50608615
Synonyms:
CHEBI:34383 | CHEMBL1162149
Type:
Small organic molecule
Emp. Form.:
C17H14N2O7S3
Mol. Mass.:
454.497
SMILES:
CC(=O)Nc1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)N=C=S)c(c1)S(O)(=O)=O
Structure:
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