Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50283059
Substrate
n/a
Meas. Tech.
ChEBML_209587
EC50
24±n/a nM
Citation
 Burk, RM; Gac, TS; Garst, ME; Gibson, LL; Krauss, AH; Protzman, CE; Woodward, DF Synthesis of a novel series of 3-oxo-2,4-dioxobicyclo[3.2.1]octanes: additional evidence for two thromboxane receptor subtypes. Bioorg Med Chem Lett 4:2103-2106 (1994)    Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50283059
Synonyms:
(Z)-7-[(1R,5S,6R,7R)-7-((E)-3-Hydroxy-oct-1-enyl)-3-oxo-2,4-dioxa-bicyclo[3.2.1]oct-6-yl]-hept-5-enoic acid | CHEMBL417967
Type:
Small organic molecule
Emp. Form.:
C21H32O6
Mol. Mass.:
380.4752
SMILES:
CCCCCC(O)\C=C\[C@H]1[C@H]2C[C@H](OC(=O)O2)[C@@H]1C\C=C/CCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: