Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM515530
Substrate
n/a
Meas. Tech.
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro
IC50
5.20±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Lustig, K; Collins, K; Lindner, N; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders US Patent  US11098063 Publication Date 8/24/2021 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM515530
Synonyms:
(3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyrimidin-3-yl]methyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)(3-fluoro-6-methoxypyridin-2-yl)methanone | US11098063, Example 22
Type:
Small organic molecule
Emp. Form.:
C26H24ClFN6O2
Mol. Mass.:
506.959
SMILES:
COc1ccc(F)c(n1)C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2 |TLB:9:11:13.14:17.35.16|
Structure:
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