Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM515579
Substrate
n/a
Meas. Tech.
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro
IC50
4.90±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Lustig, K; Collins, K; Lindner, N; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders US Patent  US11098063 Publication Date 8/24/2021 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM515579
Synonyms:
US11098063, Example 77 | US11098063, Example 78
Type:
Small organic molecule
Emp. Form.:
C30H34N6O2
Mol. Mass.:
510.63
SMILES:
COc1ccc(C)c(n1)C(=O)N1CC2CCC1CN2Cc1c(nc2ncccn12)-c1ccc(cc1)C(C)C
Structure:
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