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Target
Potassium channel subfamily K member 3
Ligand
BDBM532051
Substrate
n/a
Meas. Tech.
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis Oocytes
IC50
17.6±2.2 nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Lustig, K; Anlahr, J; Collins, K; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B; Dang, H; Duan, D; Yang, J; Chen, D Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors US Patent  US11208422 Publication Date 12/28/2021 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM532051
Synonyms:
3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl}-8-oxa-3,10-diazabicyclo[4.3.1]dec-10-yl](3-fluoro-6-methoxypyridin-2-yl)methanone (Enantiomer 1) | US11208422, Example 11 | US11208422, Example 12 | US11208422, Example 92
Type:
Small organic molecule
Emp. Form.:
C28H27ClFN5O3
Mol. Mass.:
535.997
SMILES:
COc1ccc(F)c(n1)C(=O)N1C2COCC1CN(Cc1c(nc3ccccn13)-c1ccc(Cl)cc1)CC2
Structure:
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