Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM532173
Substrate
n/a
Meas. Tech.
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro
IC50
4.10±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Lustig, K; Anlahr, J; Collins, K; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B; Dang, H; Duan, D; Yang, J; Chen, D Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors US Patent  US11208422 Publication Date 12/28/2021 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM532173
Synonyms:
US11208422, Example 21 | US11208422, Example 32
Type:
Small organic molecule
Emp. Form.:
C27H27ClN6O2
Mol. Mass.:
502.995
SMILES:
COc1cccc(n1)C(=O)N1CCC2CCC1CN2Cc1c(nc2ncccn12)-c1ccc(Cl)cc1
Structure:
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