Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM22112
Substrate
BDBM22111
Meas. Tech.
MTAP/MTAN Inhibition Assay
pH
7.0000±n/a
Temperature
295.1500±n/a K
Ki
0.45±0.05 nM
Km
430.0000±n/a nM
Citation
 Evans, GBFurneaux, RHGreatrex, BMurkin, ASSchramm, VLTyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem 51:948-56 (2008) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | P46 | S-adenosylhomocysteine nucleosidase | MTNN_ECOLI | mtnN | mtn | pfs | yadA | Methylthioadenosine Nucleosidase(MTAN)
Type:
Enzyme
Mol. Mass.:
24347.14
Organism:
Escherichia coli (strain K12)
Description:
P0AF12
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
  
Inhibitor
Name:
BDBM22112
Synonyms:
7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine | Azetidine based compound, 44
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | CHEMBL277041 | 5-methylthioadenosine | 5'-Methylthioado | (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: