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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038918
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
9.2±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038918
Synonyms:
1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL62063
Type:
Small organic molecule
Emp. Form.:
C24H18ClF2N3O
Mol. Mass.:
437.869
SMILES:
Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(-12.26,-4.7,;-10.94,-3.92,;-10.94,-2.38,;-9.61,-1.59,;-9.63,-.05,;-8.28,-2.36,;-6.95,-1.59,;-5.62,-2.36,;-5.6,-3.9,;-4.26,-4.67,;-2.93,-3.9,;-2.94,-2.36,;-1.6,-4.65,;-1.59,-6.19,;-2.92,-6.96,;-2.91,-8.5,;-1.56,-9.27,;-1.56,-10.81,;-.23,-8.48,;-.25,-6.95,;1.08,-6.17,;-6.93,-4.67,;-6.93,-6.21,;-8.28,-6.98,;-8.28,-8.52,;-6.93,-9.29,;-5.59,-8.5,;-5.59,-6.98,;-4.11,-7.38,;-8.28,-3.9,;-9.61,-4.67,)|
Structure:
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