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Target
Oxidized purine nucleoside triphosphate hydrolase
Ligand
BDBM7960
Substrate
n/a
Meas. Tech.
ChEMBL_1893593 (CHEMBL4395514)
Kd
18000±n/a nM
Citation
 Wiedmer, L; Schärer, C; Spiliotopoulos, D; Hürzeler, M; ?led?, P; Caflisch, A Ligand retargeting by binding site analogy. Eur J Med Chem 175:107-113 (2019) [PubMed]  Article 
Target
Name:
Oxidized purine nucleoside triphosphate hydrolase
Synonyms:
2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197]
Type:
Protein
Mol. Mass.:
22514.81
Organism:
Homo sapiens (Human)
Description:
P36639
Residue:
156
Sequence:
MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
  
Inhibitor
Name:
BDBM7960
Synonyms:
1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole | CHEMBL305513 | CRA Fragment 9 | Imidazole C-2 deriv. 3 | JMC524454 Compound 5 | US11584714, Compound 46
Type:
Small organic molecule
Emp. Form.:
C7H7N3
Mol. Mass.:
133.1506
SMILES:
Nc1nc2ccccc2[nH]1
Structure:
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