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Target
Cycloartenol-C-24-methyltransferase
Ligand
BDBM50134736
Substrate
n/a
Meas. Tech.
ChEMBL_203192 (CHEMBL804437)
IC50
12870±n/a nM
Citation
 Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JC; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; Urbina, J; Gonzalez Pacanowska, D; Gilbert, IH Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. J Med Chem 46:4714-27 (2003) [PubMed]  Article 
Target
Name:
Cycloartenol-C-24-methyltransferase
Synonyms:
24-sterol C-methyltransferase | CPH | SMT1 | SMT1_ARATH
Type:
PROTEIN
Mol. Mass.:
38266.01
Organism:
Arabidopsis thaliana
Description:
ChEMBL_415082
Residue:
336
Sequence:
MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE
  
Inhibitor
Name:
BDBM50134736
Synonyms:
1-{2-[1-Hydroxy-1-((3S,10S,13S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-ethyl]-piperidin-1-yl}-propan-1-one | CHEMBL143021
Type:
Small organic molecule
Emp. Form.:
C29H49NO3
Mol. Mass.:
459.7043
SMILES:
CCC(=O)N1CCCCC1C(C)(O)[C@H]1CCC2C3CCC4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C
Structure:
Search PDB for entries with ligand similarity: