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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50142655
Substrate
n/a
Meas. Tech.
ChEBML_68376
EC50
2500±n/a nM
Citation
 Guo, T; Adang, AE; Dolle, RE; Dong, G; Fitzpatrick, D; Geng, P; Ho, KK; Kultgen, SG; Liu, R; McDonald, E; McGuinness, BF; Saionz, KW; Valenzano, KJ; van Straten, NC; Xie, D; Webb, ML Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis. Bioorg Med Chem Lett 14:1713-6 (2004) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50142655
Synonyms:
2-{4-[4'-(1-Butyl-3-methyl-ureidomethyl)-biphenyl-4-ylmethyl]-3-methyl-2,5-dioxo-imidazolidin-1-yl}-N-hexyl-acetamide | CHEMBL417173
Type:
Small organic molecule
Emp. Form.:
C32H45N5O4
Mol. Mass.:
563.7308
SMILES:
CCCCCCNC(=O)Cn1c(O)c(Cc2ccc(cc2)-c2ccc(CN(CCCC)C(=O)NC)cc2)n(C)c1=O
Structure:
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