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Target
Integrase
Ligand
BDBM50410310
Substrate
n/a
Meas. Tech.
ChEMBL_305660 (CHEMBL829517)
IC50
10±n/a nM
Citation
 Verschueren, WG; Dierynck, I; Amssoms, KI; Hu, L; Boonants, PM; Pille, GM; Daeyaert, FF; Hertogs, K; Surleraux, DL; Wigerinck, PB Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase. J Med Chem 48:1930-40 (2005) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50410310
Synonyms:
CHEMBL2079773
Type:
Small organic molecule
Emp. Form.:
C20H17FN4O4S
Mol. Mass.:
428.438
SMILES:
[O-]c1c(nc(N2CCCCS2(=O)=O)c2cccnc12)C(=O)[N-]Cc1ccc(F)cc1
Structure:
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