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Target
Integrase
Ligand
BDBM50422709
Substrate
n/a
Meas. Tech.
ChEMBL_307268 (CHEMBL831653)
IC50
1000±n/a nM
Citation
 Verschueren, WG; Dierynck, I; Amssoms, KI; Hu, L; Boonants, PM; Pille, GM; Daeyaert, FF; Hertogs, K; Surleraux, DL; Wigerinck, PB Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase. J Med Chem 48:1930-40 (2005) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50422709
Synonyms:
CHEMBL174851
Type:
Small organic molecule
Emp. Form.:
C23H14FN3O4
Mol. Mass.:
415.3734
SMILES:
Fc1ccccc1-c1ccc(Cn2c(=O)c3c(c2=O)c(=O)c2[nH]cc[nH]c2c3=O)cc1
Structure:
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