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Target
D-amino-acid oxidase
Ligand
BDBM50605582
Substrate
n/a
Meas. Tech.
ChEMBL_2252183 (CHEMBL5166393)
EC50
3800±n/a nM
Citation
 Tang, H; Jensen, K; Houang, E; McRobb, FM; Bhat, S; Svensson, M; Bochevarov, A; Day, T; Dahlgren, MK; Bell, JA; Frye, L; Skene, RJ; Lewis, JH; Osborne, JD; Tierney, JP; Gordon, JA; Palomero, MA; Gallati, C; Chapman, RSL; Jones, DR; Hirst, KL; Sephton, M; Chauhan, A; Sharpe, A; Tardia, P; Dechaux, EA; Taylor, A; Waddell, RD; Valentine, A; Janssens, HB; Aziz, O; Bloomfield, DE; Ladha, S; Fraser, IJ; Ellard, JM Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform. J Med Chem 65:6775-6802 (2022) [PubMed] 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50605582
Synonyms:
CHEMBL5205206
Type:
Small organic molecule
Emp. Form.:
C12H9N3O2S
Mol. Mass.:
259.284
SMILES:
O=c1[nH]cc(SCc2cccc(c2)C#N)[nH]c1=O
Structure:
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