Reaction Details Report a problem with these data
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Ligand
BDBM50611012
Substrate
n/a
Meas. Tech.
ChEMBL_2282735
IC50
40±n/a nM
Citation
 Wortmann, L; Bräuer, N; Holton, SJ; Irlbacher, H; Weiske, J; Lechner, C; Meier, R; Karén, J; Siöberg, CB; Pütter, V; Christ, CD; Ter Laak, A; Lienau, P; Lesche, R; Nicke, B; Cheung, SH; Bauser, M; Haegebarth, A; von Nussbaum, F; Mumberg, D; Lemos, C Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J Med Chem 64:15883-15911 (2021) [PubMed] 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Synonyms:
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha
Type:
PROTEIN
Mol. Mass.:
46228.59
Organism:
Homo sapiens
Description:
ChEMBL_104274
Residue:
406
Sequence:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
  
Inhibitor
Name:
BDBM50611012
Synonyms:
CHEMBL5284796
Type:
Small organic molecule
Emp. Form.:
C28H27N5O4S
Mol. Mass.:
529.61
SMILES:
CCOc1ccccc1-c1ccc(cc1)-c1nc2cnccc2c(N[C@H](CC)C(=O)NS(C)(=O)=O)c1C#N |r|
Structure:
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