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Target
DNA polymerase beta
Ligand
BDBM50240866
Substrate
n/a
Meas. Tech.
ChEMBL_481421 (CHEMBL1008679)
IC50
45200±n/a nM
Citation
 Cao, S; Gao, Z; Thomas, SJ; Hecht, SM; Lazo, JS; Kingston, DG Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. J Nat Prod 67:1716-8 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50240866
Synonyms:
(-)-ilimaquinone | 2-Hydroxy-5-methoxy-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone | CHEMBL155085 | Ilimaquinone
Type:
Small organic molecule
Emp. Form.:
C22H30O4
Mol. Mass.:
358.4712
SMILES:
COC1=CC(=O)C(=O)C(C[C@]2(C)[C@@H](C)CC[C@@]3(C)[C@H]2CCCC3=C)C1=O |r,t:2|
Structure:
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