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Target
Histone deacetylase 1
Ligand
BDBM50257130
Substrate
n/a
Meas. Tech.
ChEMBL_562513 (CHEMBL1014505)
IC50
64±n/a nM
Citation
 Manku, S; Allan, M; Nguyen, N; Ajamian, A; Rodrigue, J; Therrien, E; Wang, J; Guo, T; Rahil, J; Petschner, AJ; Nicolescu, A; Lefebvre, S; Li, Z; Fournel, M; Besterman, JM; Déziel, R; Wahhab, A Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors. Bioorg Med Chem Lett 19:1866-70 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50257130
Synonyms:
(S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamido)-N-(4-phenylthiazol-2-yl)-6-(sulfamoylamino)hexanamide | CHEMBL494124
Type:
Small organic molecule
Emp. Form.:
C27H32N6O5S2
Mol. Mass.:
584.71
SMILES:
COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCNS(N)(=O)=O)C(=O)Nc3nc(cs3)-c3ccccc3)c2c1 |r|
Structure:
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