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Target
2-5A-dependent ribonuclease
Ligand
BDBM50021104
Substrate
n/a
Meas. Tech.
ChEMBL_164152 (CHEMBL770786)
IC50
2300±n/a nM
Citation
 Sawai, H; Lesiak, K; Imai, J; Torrence, PF Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine. J Med Chem 28:1376-80 (1985) [PubMed]  Article 
Target
Name:
2-5A-dependent ribonuclease
Synonyms:
2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_HUMAN | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L
Type:
PROTEIN
Mol. Mass.:
83534.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_164152
Residue:
741
Sequence:
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC
  
Inhibitor
Name:
BDBM50021104
Synonyms:
(2'-5'(pAris)3
Type:
Small organic molecule
Emp. Form.:
C33H40N15O16P3
Mol. Mass.:
995.6851
SMILES:
Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Structure:
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