Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Yes
Ligand
BDBM50221547
Substrate
n/a
Meas. Tech.
ChEMBL_473236 (CHEMBL932927)
IC50
4.8±n/a nM
Citation
 Palanki, MS; Akiyama, H; Campochiaro, P; Cao, J; Chow, CP; Dellamary, L; Doukas, J; Fine, R; Gritzen, C; Hood, JD; Hu, S; Kachi, S; Kang, X; Klebansky, B; Kousba, A; Lohse, D; Mak, CC; Martin, M; McPherson, A; Pathak, VP; Renick, J; Soll, R; Umeda, N; Yee, S; Yokoi, K; Zeng, B; Zhu, H; Noronha, G Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. J Med Chem 51:1546-59 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Yes
Synonyms:
Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes
Type:
Protein
Mol. Mass.:
60801.54
Organism:
Homo sapiens (Human)
Description:
P07947
Residue:
543
Sequence:
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50221547
Synonyms:
4-chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)propyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol | 7-(2-chloro-5-hydroxyphenyl)-5-methyl-N-[4-(3-pyrrolidin-1-ylpropyl)]phenyl]-1,2,4-benzotriazin-3-amine | CHEMBL250213
Type:
Small organic molecule
Emp. Form.:
C27H28ClN5O
Mol. Mass.:
473.997
SMILES:
Cc1cc(cc2nnc(Nc3ccc(CCCN4CCCC4)cc3)nc12)-c1cc(O)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: