Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50259951
Substrate
n/a
Meas. Tech.
ChEMBL_549472 (CHEMBL997270)
IC50
3000±n/a nM
Citation
 De Rosa, S; Crispino, A; De Giulio, A; Iodice, C; Benrezzouk, R; Terencio, MC; Ferrándiz, ML; Alcaraz, MJ; Payá, M A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. J Nat Prod 61:931-5 (1998) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50259951
Synonyms:
CHEMBL480681 | cacospongionolide
Type:
Small organic molecule
Emp. Form.:
C25H36O4
Mol. Mass.:
400.5509
SMILES:
C[C@H]1CC[C@@]23C[C@]2(C)CCC[C@@H]3[C@@]1(C)CCC1=CC[C@@H](OC1)C1=CC(=O)O[C@H]1O |r,t:19,26|
Structure:
Search PDB for entries with ligand similarity: