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Target
Ephrin type-A receptor 3
Ligand
BDBM50302165
Substrate
n/a
Meas. Tech.
ChEMBL_599561 (CHEMBL1038371)
IC50
9000±n/a nM
Citation
 Wu, JP; Fleck, R; Brickwood, J; Capolino, A; Catron, K; Chen, Z; Cywin, C; Emeigh, J; Foerst, M; Ginn, J; Hrapchak, M; Hickey, E; Hao, MH; Kashem, M; Li, J; Liu, W; Morwick, T; Nelson, R; Marshall, D; Martin, L; Nemoto, P; Potocki, I; Liuzzi, M; Peet, GW; Scouten, E; Stefany, D; Turner, M; Weldon, S; Zimmitti, C; Spero, D; Kelly, TA The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II. Bioorg Med Chem Lett 19:5547-51 (2009) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 3
Synonyms:
EPHA3 | EPHA3_HUMAN | ETK | ETK1 | Ephrin receptor | Ephrin type-A receptor 3 | Ephrin type-A receptor 3 (EPHA3) | HEK | TYRO4
Type:
Protein
Mol. Mass.:
110131.95
Organism:
Homo sapiens (Human)
Description:
P29320
Residue:
983
Sequence:
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
  
Inhibitor
Name:
BDBM50302165
Synonyms:
3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxamide | CHEMBL576887
Type:
Small organic molecule
Emp. Form.:
C16H22N4O2S
Mol. Mass.:
334.436
SMILES:
CCCc1cc(nc2sc(C(N)=O)c(N)c12)N1CCC(O)CC1
Structure:
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