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Target
Cyclin-dependent kinase 2
Ligand
BDBM50388785
Substrate
n/a
Meas. Tech.
ChEMBL_830913 (CHEMBL2065462)
IC50
>30000±n/a nM
Citation
 Dowling, JE; Chuaqui, C; Pontz, TW; Lyne, PD; Larsen, NA; Block, MH; Chen, H; Su, N; Wu, A; Russell, D; Pollard, H; Lee, JW; Peng, B; Thakur, K; Ye, Q; Zhang, T; Brassil, P; Racicot, V; Bao, L; Denz, CR; Cooke, E Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett 3:278-283 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50388785
Synonyms:
CHEMBL2062577
Type:
Small organic molecule
Emp. Form.:
C21H19N7O
Mol. Mass.:
385.4219
SMILES:
CN(C(C)=O)c1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1
Structure:
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