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Found 1134 with Last Name = 'lee' and Initial = 'jw'
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataKi:  1nMAssay Description:Binding affinity to PPARdelta (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  2nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataKi:  7nMAssay Description:Binding affinity to PPARalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278443(1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-m...)
Affinity DataKi:  58nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175018(4,7,8-trihydroxy-2,3,3-trimethyl-9-(3-methylbut-2-...)
Affinity DataKi:  98nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50378020(MACLURAXANTHONE)
Affinity DataKi:  103nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278443(1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-m...)
Affinity DataKi:  127nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278346(CHEMBL470844 | Cudratricusxanthone)
Affinity DataKi:  136nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175013(1,3,6,7-tetrahydroxy-5-(3-methylbut-2-enyl)-2-(2-m...)
Affinity DataKi:  138nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175019(2,3,8-trihydroxy-6-methoxy-1-(3-methylbut-2-enyl)-...)
Affinity DataKi:  143nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278346(CHEMBL470844 | Cudratricusxanthone)
Affinity DataKi:  214nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175019(2,3,8-trihydroxy-6-methoxy-1-(3-methylbut-2-enyl)-...)
Affinity DataKi:  436nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50378020(MACLURAXANTHONE)
Affinity DataKi:  477nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175018(4,7,8-trihydroxy-2,3,3-trimethyl-9-(3-methylbut-2-...)
Affinity DataKi:  510nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50175013(1,3,6,7-tetrahydroxy-5-(3-methylbut-2-enyl)-2-(2-m...)
Affinity DataKi:  568nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataKi:  600nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278394(CHEMBL469813 | Cudratricusxanthone F)
Affinity DataKi:  950nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot and Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Graduate School Of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50278394(CHEMBL469813 | Cudratricusxanthone F)
Affinity DataKi:  2.23E+3nMAssay Description:Apparent binding affinity at Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84968(Urea derivative, 12)
Affinity DataKi:  3.20E+3nM IC50:  8.40E+3nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol-trisphosphate 3-kinase A(Homo sapiens (Human))
New York University

LigandPNGBDBM82310(Purine, 5)
Affinity DataKi:  4.30E+3nM ΔG°:  -31.9kJ/mole IC50:  1.02E+4nMpH: 8.0 T: 2°CAssay Description:IP3K reactions were carried out in a 100ul solution that contained Tris-Cl, EGTA, ATP, DTT, 2,3-diphosphoglycerate, D-l(1,4,5)P3, [3H]-l(1,4,5)P3 and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84969(Urea derivative, 13)
Affinity DataKi:  4.60E+3nM IC50:  1.43E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50607786(CHEMBL5220260)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84967(Urea derivative, 11)
Affinity DataKi:  7.20E+3nM IC50:  1.98E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84972(Urea derivative, 16)
Affinity DataKi:  9.40E+3nM IC50:  1.85E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50607785(CHEMBL5219536)
Affinity DataKi:  9.40E+3nMAssay Description:Binding affinity to PPARalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84963(Urea derivative, 7)
Affinity DataKi:  1.05E+4nM IC50:  1.95E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84962(Urea derivative, 6)
Affinity DataKi:  1.06E+4nM IC50:  4.21E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84966(Urea derivative, 10)
Affinity DataKi:  1.21E+4nM IC50:  2.88E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84970(Urea derivative, 14)
Affinity DataKi:  1.70E+4nM IC50:  2.91E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.80E+4nM IC50:  3.95E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50607785(CHEMBL5219536)
Affinity DataKi:  1.88E+4nMAssay Description:Binding affinity to PPARdelta (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50607785(CHEMBL5219536)
Affinity DataKi:  1.91E+4nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataKi:  2.15E+4nM IC50:  2.64E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM84959(Stilbene derivative, 2)
Affinity DataKi:  3.51E+4nM IC50:  4.64E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50569109(CHEMBL4868857)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254040(US9493430, 593)
Affinity DataIC50:  1.5nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254048(US9493430, 618)
Affinity DataIC50:  1.60nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254050(US9493430, 631)
Affinity DataIC50:  1.90nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254058(US9493430, 684)
Affinity DataIC50:  1.90nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254054(US9493430, 661)
Affinity DataIC50:  2.5nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CSF1R (unknown origin) (538 to 972 residues) expressed in baculovirus expression system using SYEGNSYTFIDPTQ as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254034(US9493430, 574)
Affinity DataIC50:  3.90nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518533(CHEMBL4521506)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388788(CHEMBL2062566)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminus His-tagged human CK2alpha expressed in insect Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388805(CHEMBL2062571)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminus His-tagged human CK2alpha expressed in insect Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518525(CHEMBL4454948)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518528(CHEMBL4476544)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Incheon University Industry Academic Cooperation Foundation

US Patent
LigandPNGBDBM473585(US10844062, Example 21)
Affinity DataIC50:  4.10nMAssay Description:The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254055(US9493430, 668)
Affinity DataIC50:  5nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518526(CHEMBL4436695)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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