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Target
Death-associated protein kinase 2
Ligand
BDBM50166251
Substrate
n/a
Meas. Tech.
ChEMBL_1575379 (CHEMBL3802097)
IC50
170±n/a nM
Citation
 Jung, ME; Byun, BJ; Kim, HM; Lee, JY; Park, JH; Lee, N; Son, YH; Choi, SU; Yang, KM; Kim, SJ; Lee, K; Kim, YC; Choi, G Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening. Bioorg Med Chem Lett 26:2719-23 (2016) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 2
Synonyms:
DAP kinase 2 | DAP-kinase-related protein 1 | DAPK2 | DAPK2_HUMAN | DRP-1
Type:
PROTEIN
Mol. Mass.:
42900.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774557
Residue:
370
Sequence:
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
  
Inhibitor
Name:
BDBM50166251
Synonyms:
CHEMBL3799389
Type:
Small organic molecule
Emp. Form.:
C20H16N4O3
Mol. Mass.:
360.366
SMILES:
O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)C3CC3)cc12
Structure:
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