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Target
Eyes absent homolog 2 [253-538]
Ligand
BDBM231625
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
6.5±0
Temperature
298.15±0 K
Kd
6.1e+3± 1.2e+3 nM
Citation
 Krueger, AB; Drasin, DJ; Lea, WA; Patrick, AN; Patnaik, S; Backos, DS; Matheson, CJ; Hu, X; Barnaeva, E; Holliday, MJ; Blevins, MA; Robin, TP; Eisenmesser, EZ; Ferrer, M; Simeonov, A; Southall, N; Reigan, P; Marugan, J; Ford, HL; Zhao, R Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem 289:16349-61 (2014) [PubMed]  Article 
Target
Name:
Eyes absent homolog 2 [253-538]
Synonyms:
EAB1 | EYA2 | EYA2_HUMAN | Eye absent protein 2 Eya domain (Eya2 ED)
Type:
Protein
Mol. Mass.:
32198.63
Organism:
Homo sapiens (Human)
Description:
Human Eya2 ED (253-538 aa)
Residue:
286
Sequence:
SKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
  
Inhibitor
Name:
BDBM231625
Synonyms:
MLS000544460
Type:
Small organic molecule
Emp. Form.:
C17H12FN3O2S
Mol. Mass.:
341.359
SMILES:
Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Structure:
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