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Target
Potassium channel subfamily K member 9
Ligand
BDBM459030
Substrate
n/a
Meas. Tech.
Inhibition In Vito Assay
IC50
5.20±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders US Patent  US10759794 Publication Date 9/1/2020 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM459030
Synonyms:
(4-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(3-fluoro-6-methoxypyridin-2-yl)methanone | US10759794, Example 68
Type:
Small organic molecule
Emp. Form.:
C25H23ClFN5O2
Mol. Mass.:
479.934
SMILES:
COc1ccc(F)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
Structure:
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