Reaction Details Report a problem with these data
Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM276744
Substrate
n/a
Meas. Tech.
Human, Dog and Rat c-Fms Enzyme Assay
IC50
2.20±n/a nM
Citation
 Chen, J; Donahue, M; Lim, H; Lin, R; Salter, R; Wu, J; Gong, Y Substituted pyridine derivatives useful as C-FMS kinase inhibitors US Patent  US10800764 Publication Date 10/13/2020 
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CD_antigen: CD115 | CSF-1 receptor | CSF-1-R | CSF-1R | CSF1R_RAT | Csf1r | Csfmr | Fms | M-CSF-R | Proto-oncogene c-Fms
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109259.61
Organism:
Rattus norvegicus (Rat)
Description:
Q00495
Residue:
978
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFAC
  
Inhibitor
Name:
BDBM276744
Synonyms:
US10071991, Compound (I-M2-2S,4R) | US10800764, Compound (I-M7-2R,4S) | US11214566, Compound (I-M2-2S,4R)
Type:
Small organic molecule
Emp. Form.:
C27H33N5O4
Mol. Mass.:
491.582
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O |r,c:5|
Structure:
Search PDB for entries with ligand similarity: