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Target
Orexin receptor type 2
Ligand
BDBM479227
Substrate
n/a
Meas. Tech.
Orexin Receptor Cell-Based Functional Assay
IC50
>5000±n/a nM
Citation
 Kamenecka, TM; Holenz, J; Wesolowski, S; He, Y; Bürli, R Halo-substituted piperidines as orexin receptor modulators US Patent  US10894789 Publication Date 1/19/2021 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM479227
Synonyms:
US10894789, Compound 211
Type:
Small organic molecule
Emp. Form.:
C22H21F5N6OS
Mol. Mass.:
512.499
SMILES:
C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccn1 |r|
Structure:
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