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TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601510BDBM50601510(CHEMBL5170838)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601479BDBM50601479(CHEMBL5182746)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285607BDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594972BDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601508BDBM50601508(CHEMBL5206652)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 320991BDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601511BDBM50601511(CHEMBL5181979)
Affinity DataIC50: 1nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601501BDBM50601501(CHEMBL5173723)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601494BDBM50601494(CHEMBL5192493)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601496BDBM50601496(CHEMBL5197178)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285607BDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285607BDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE1/UBA3 in human HCT-116 cells assessed as reduction in Ubc12-NEDD8 level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601503BDBM50601503(CHEMBL5209054)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285607BDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601509BDBM50601509(CHEMBL5188530)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601502BDBM50601502(CHEMBL5193236)
Affinity DataIC50: 6nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601482BDBM50601482(CHEMBL5177700)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601511BDBM50601511(CHEMBL5181979)
Affinity DataIC50: 8nMAssay Description:Inhibition of NAE in human HCT-116 cells incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601505BDBM50601505(CHEMBL5178136)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601507BDBM50601507(CHEMBL5192527)
Affinity DataIC50: 10nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575579BDBM50575579(CHEMBL4847817)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50427035BDBM50427035(CHEMBL2017005)
Affinity DataIC50: 10nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601484BDBM50601484(CHEMBL5169743)
Affinity DataIC50: 16nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601504BDBM50601504(CHEMBL5179467)
Affinity DataIC50: 21nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601488BDBM50601488(CHEMBL5170141)
Affinity DataIC50: 21nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575577BDBM50575577(CHEMBL4860740)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575555BDBM50575555(CHEMBL4878088)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285607BDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  30nMAssay Description:Inhibition of NAE in human HCT-116 cells incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601483BDBM50601483(CHEMBL5207989)
Affinity DataIC50: 31nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575593BDBM50575593(CHEMBL4878832)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575562BDBM50575562(CHEMBL4852015)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 462715BDBM462715({(1R,2S,4R)-4-[(5-{[4-(3-chlorobenzyl)-5-methyl-2-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575586BDBM50575586(CHEMBL4848442)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 462705BDBM462705(US10780090, Compound I-43 | {(1R,2S,4R)-4-[(5-{[4-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601499BDBM50601499(CHEMBL5201960)
Affinity DataIC50: 67nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601490BDBM50601490(CHEMBL5206263)
Affinity DataIC50: 81nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601485BDBM50601485(CHEMBL5206633)
Affinity DataIC50: 82nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 462725BDBM462725(US10780090, Compound I-59 | {(1R,2S,4R)-4-[(5-{[4-...)
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 762712BDBM762712(US12378251, Compound S14)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762711BDBM762711(US12378251, Compound S13)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762700BDBM762700(US12378251, Compound S2)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762554BDBM762554(US12378251, Compound S1)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762702BDBM762702(US12378251, Compound S4)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762718BDBM762718(US12378251, Compound S20)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762701BDBM762701(US12378251, Compound S3)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762704BDBM762704(US12378251, Compound S6)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 393526BDBM393526(US9963456, Example Comp. | US12378251, Compound ML...)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 762706BDBM762706(US12378251, Compound S8)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762708BDBM762708(US12378251, Compound S10)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 762707BDBM762707(US12378251, Compound S9)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent

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