Compile Data Set for Download or QSAR
Report error Found 6860 of affinity data for UniProtKB/TrEMBL: P35414
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422122(US10508104, Example 15 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  0.00200nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422140(US10508104, Example 32 | 1-(2,6- dimethoxyphenyl)-...)
Affinity DataEC50:  0.0100nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422138(US10508104, Example 30 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  0.0100nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataEC50:  0.0120nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50078007(CHEMBL3417384)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588327(CHEMBL5192130)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588329(CHEMBL5173464)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588328(CHEMBL5208127)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588331(CHEMBL5193130)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567168(CHEMBL4864542)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588333(CHEMBL5202635)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50078007(CHEMBL3417384)
Affinity DataIC50: 0.0200nMAssay Description:Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422180(2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50566289(CHEMBL4878158)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588322(CHEMBL5205562)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50577755(CHEMBL4861895)
Affinity DataEC50:  0.0230nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0230nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0230nMAssay Description:Agonist activity at human APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50577753(CHEMBL4854412)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567167(CHEMBL4872192)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588326(CHEMBL5202233)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422160(N-[4-(4-{[2-butyl-1- (2,6-dimethoxyphenyl)- 6-hydr...)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588332(CHEMBL5175424)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567164(CHEMBL4848436)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM270203((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Affinity DataEC50:  0.0320nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50577754(CHEMBL4867145)
Affinity DataEC50:  0.0320nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM270203((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Affinity DataEC50:  0.0320nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM270203((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Affinity DataEC50:  0.0320nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50566283(CHEMBL4876632)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588330(CHEMBL5197398)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567160(CHEMBL4873216)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50078006(CHEMBL3417385)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567163(CHEMBL4863554)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataEC50:  0.0470nMAssay Description:Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293 cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM448014(US10689367, Example 343.0 | US10689367, Example 34...)
Affinity DataEC50:  0.0500nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422120(US10508104, Example 13 | 1-(2,6- dimethoxyphenyl)-...)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014620(CHEMBL414173)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567161(CHEMBL4850818)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM456669(US10736883, Example 116.0)
Affinity DataEC50:  0.0560nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM456867(US10736883, Example 383.0)
Affinity DataEC50:  0.0600nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50588316(CHEMBL5170657)
Affinity DataEC50:  0.0600nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM456670(US10736883, Example 117.0)
Affinity DataEC50:  0.0610nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM269647((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Affinity DataEC50:  0.0620nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50506019(CHEMBL4473347)
Affinity DataEC50:  0.0620nMAssay Description:Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM269647((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Affinity DataEC50:  0.0620nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM269647((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Affinity DataEC50:  0.0620nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM447997(US10689367, Example 328.0 | US10689367, Example 32...)
Affinity DataEC50:  0.0640nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

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