Compile Data Set for Download or QSAR
Report error Found 137 of affinity data for UniProtKB/TrEMBL: P70596
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50165931(NDP-SYSMEHFRWGKPVG | CHEMBL415165)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity for rat melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.280nMAssay Description:Inhibition of rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50521263(CHEMBL4541658)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50165936(Ac-dR[CEHdFRWC]-NH2 | CHEMBL267900)
Affinity DataKi:  0.390nMAssay Description:Binding affinity for rat melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50521266(CHEMBL4463571)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367219(CHEMBL4165147)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373472(CHEMBL429854)
Affinity DataEC50:  0.5nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373479(CHEMBL254757)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50165930(Ac-YR[CEHdFRWC]-NH2 | CHEMBL264352)
Affinity DataKi:  0.520nMAssay Description:Binding affinity for rat melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from rat MC4R expressed in CHO cells by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563845(CHEMBL4793371)
Affinity DataEC50:  0.540nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563860(CHEMBL4788206)
Affinity DataEC50:  0.590nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 0.600nMAssay Description:Evaluated for binding affinity against rat Melanocortin-4 receptor (rMC4R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563857(CHEMBL4797858)
Affinity DataEC50:  0.830nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563858(CHEMBL4785057)
Affinity DataEC50:  0.890nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373487(CHEMBL254589)
Affinity DataEC50:  0.900nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563848(CHEMBL4782004)
Affinity DataEC50:  0.930nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563843(CHEMBL4798993)
Affinity DataEC50:  1nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373474(CHEMBL402769)
Affinity DataIC50: 1nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  1nMAssay Description:Binding affinity at rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at rat melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563846(CHEMBL4787010)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563849(CHEMBL4797124)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367218(CHEMBL4159416)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563854(CHEMBL4791842)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM392656(US10301286, Example 4)
Affinity DataEC50:  1.30nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563842(CHEMBL4798023)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373476(CHEMBL255286)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373472(CHEMBL429854)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM392660(US10301286, Example 76)
Affinity DataEC50:  1.70nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563863(CHEMBL4787498)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM293981(US10106553, Compound 13 | (2S)-5-(2-(4-((3-(2- (Tr...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50314764(trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-di...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at rat MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  2nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563856(CHEMBL4800563)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367222(CHEMBL4162778)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM392658(US10301286, Example 9)
Affinity DataEC50:  2.60nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.90nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-4 receptor (rMC4R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563844(CHEMBL4781604)
Affinity DataEC50:  3nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204012(CHEMBL3955132)
Affinity DataEC50:  3nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM392663(US10301286, Example 89)
Affinity DataEC50:  3.10nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50362690(CHEMBL1829173 | AMG-837)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM293976(US10106553, Compound 8 | (2S)-5-(2-(4-((3-(4-(2- M...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM293975(US10106553, Compound 7 | (2S)-4-(4-(5-((4-(1-(1H- ...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50521269(CHEMBL4591657)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563847(CHEMBL4792075)
Affinity DataEC50:  4.20nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563862(CHEMBL4799453)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50563859(CHEMBL4786335)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50521267(CHEMBL4513748)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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