Compile Data Set for Download or QSAR
Report error Found 311 of affinity data for UniProtKB/TrEMBL: Q15746
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  0.317nMAssay Description:Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 10nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd:  11nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to MLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  13nMAssay Description:Binding affinity to MYLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  13nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  15nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  15nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  15nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2580(methyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28...)
Affinity DataKi:  17nMAssay Description:Inhibition of human myosin light chain kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50: 18nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataKi:  20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  23nMAssay Description:Binding affinity to MLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50118955(Compound K-252a(epi) | CHEMBL94678)
Affinity DataIC50: 25nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50: 30nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50284317(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Affinity DataIC50: 32nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 43.2nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3045(3-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50: 49nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 51.3nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3043(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Affinity DataIC50: 55nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  97nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50284318(13-(3-dimethylamino-2-hydroxypropyl)-3-methoxy-12-...)
Affinity DataIC50: 120nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50: 120nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataKd:  150nMAssay Description:Binding affinity to human SKMLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataIC50: 170nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3046(3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...)
Affinity DataIC50: 180nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50: 200nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307648(US10150755, Compound 40 | 2-(6-(4-cyclopropyl- 4H-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307649(US10150755, Compound 41 | 2-(6-(4-cyclopropyl- 4H-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307672(US10150755, Compound 64 | 2-(6-(4-cyclopropyl-4H-1...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307674(US10150755, Compound 66 | 2-(6-(4-cyclopropyl-4H-1...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307609(US10150755, Compound 1 | 2-(6-(4-Cyclopropyl-4H-1,...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307686(US10150755, Compound 78 | 2-(6-(5-methyl-6,7-dihyd...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307654(BDBM307669 | 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM307668(US10150755, Compound 60 | 2-(6-(4-cyclopropyl- 4H-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  206nMAssay Description:Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  220nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3037(23-[3-(dimethylamino)propyl]-7,19-dimethoxy-3,13,2...)
Affinity DataIC50: 220nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  220nMAssay Description:Binding affinity to MYLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3039(23-[3-(dimethylamino)propyl]-3-methyl-3,13,23-tria...)
Affinity DataIC50: 250nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50: 265nMAssay Description:Inhibition of MYLK in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  280nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  280nMAssay Description:Binding affinity to MYLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  280nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  280nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  290nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  290nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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