Compile Data Set for Download or QSAR
Report error Found 54 of affinity data for UniProtKB/TrEMBL: Q8WWU9
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591915BDBM50591915(CHEMBL2130955)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591915BDBM50591915(CHEMBL2130955)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591915BDBM50591915(CHEMBL2130955)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50108052BDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618185BDBM50618185(CHEMBL5406721)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618193BDBM50618193(CHEMBL5418617)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618191BDBM50618191(CHEMBL5429178)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591915BDBM50591915(CHEMBL2130955)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618198BDBM50618198(CHEMBL5406218)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50388532BDBM50388532(CHEMBL2058833)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505550BDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618183BDBM50618183(CHEMBL5406156)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618184BDBM50618184(CHEMBL5401832)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50508662BDBM50508662(CHEMBL4435025)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618187BDBM50618187(CHEMBL5426573)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618188BDBM50618188(CHEMBL5396198)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618186BDBM50618186(CHEMBL5395150)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618189BDBM50618189(CHEMBL5406117)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618190BDBM50618190(CHEMBL380753)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014323BDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618194BDBM50618194(CHEMBL5405212)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244440BDBM50244440(CHEMBL4065122)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human liver microsome CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618192BDBM50618192(CHEMBL5438759)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543383BDBM50543383(CHEMBL4634904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human liver microsome CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618199BDBM50618199(CHEMBL5425709)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618195BDBM50618195(CHEMBL5412548)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618197BDBM50618197(CHEMBL5394220)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618200BDBM50618200(CHEMBL5401046)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550026BDBM50550026(CHEMBL4786690)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017716BDBM50017716(CHEMBL282567 | 2-Benzhydryl-pentanoic acid 2-dieth...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512922BDBM50512922(CHEMBL4533700)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512926BDBM50512926(CHEMBL4554389)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512919BDBM50512919(CHEMBL4554158)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541296BDBM50541296(CHEMBL4636169)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589165BDBM50589165(CHEMBL4288940)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50613392BDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541318BDBM50541318(CHEMBL4632688)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50365230BDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511451BDBM50511451(CHEMBL4570428)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP isoform (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 368657BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 368625BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512931BDBM50512931(CHEMBL4528928)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 330295BDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 413450BDBM413450(US10407446, Example 3 | 7-methyl-2-((7-methyl-[1,2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 264212BDBM264212((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Cytochrome P450More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618894BDBM50618894(CHEMBL5393771)
Affinity DataIC50: 3.30E+4nMAssay Description:Time dependent inhibition of CYP450 in human liver microsomes prewarmed for 5 mins followed by incubation with midazolam substrate for 20 mins and la...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 364746BDBM364746(US9862730, Example 205 | 6-(4-((3-(Benzyloxy)benzy...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP450 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536234BDBM50536234(CHEMBL4580214)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593627BDBM50593627(CHEMBL5199558)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543291BDBM50543291(CHEMBL4644751)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
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